医学免疫学 留学生与双语教学 用英文原版改编版
作者：苏尼尔 库马尔 莫汉蒂
出版时间：2017年版
内容简介
医学免疫学是一门独立的学科，是研究免疫系统的组织结构和功能的科学。它从不同的角度和水平来揭示免疫系统识别并消除抗原性异物的应答过程和规律，并应用这些规律来阐明免疫相关疾病发生发展的机制，达到防治相关疾病的目的。医学免疫学进展迅速，知识量大，本教材基于*基本的理论和知识，介绍了抗原、免疫器官和免疫细胞、免疫分子（抗体、补体、细胞因子、黏附分子和 MHC等）、免疫应答、免疫预防、免疫治疗、免疫诊断、免疫耐受、免疫相关疾病以及感染免疫等。本教材适用于医学专业外国留学生的医学免疫学英文教学和本科双语教学。
目录
Chapter 1 Introduction......................................... 1
A BRIEF OVERVIEW OF IMMUNOLOGY................. 1
HIST ORY OF IMMUNOLOGY................................... 10
STUDY QUESTIONS.................................................... 13
Suggested readingS .......................................... 13
Chapter 2 Antigen.................................................... 14
DEFINITION................................................................. 14
Epitopes...................................................................... 14
Classification of Antigens BASED ON
IMMUNE RESPONSE............................................. 15
DETERMINANTS OF IMMUNOGENICITY............ 15
ANTIGEN RECEPTORS.............................................. 16
ANTIGENIC SPECIFICITY......................................... 17
STUDY QUESTIONS ................................................... 18
Suggested readingS........................................... 18
Chapter 3 Antigen Recognition Molecules
....................................................................... 19
ANTIBODIES—IMMUNOGLOBULINS................... 20
Major Histocompatibility Complex ......... 25
STUDY QUESTIONS.................................................... 28
Suggested ReadingS........................................... 28
Chapter 4 The Complement System............ 29
Complement Activation................................. 29
Regulation of the Complement
System ................................................................. 31
Biological Consequences of
Complement Activation.............................. 32
Defects in the Complement System........... 34
STUDY QUESTIONS ................................................... 34
Suggested readingS........................................... 35
Chapter 5 Organs and Tissues of the
Immune System................................. 36
LYMPHOID ORGANS................................................. 36
Contents
STUDY QUESTIONS.................................................... 39
Suggested ReadingS........................................... 39
Chapter 6 Immune Cells...................................... 41
Lymphocytes........................................................... 41
Phagocytic Cells................................................. 47
Dendritic Cells .................................................... 48
STUDY QUESTIONS.................................................... 48
Suggested ReadingS........................................... 48
Chapter 7 Immune Response............................ 49
AN TIGEN PROCESSING AND
PRESENTATION................................................... 49
AC TIVATION OF HELPER T LYMPHOCYTES.......... 51
HU MORAL IMMUNE RESPONSE
(HUMORAL IMMUNITY).................................... 55
PRIMARY AND SECONDARY RESPONSE ........... 58
FA CTORS INFLUENCING ANTIBODY
PRODUCTION........................................................ 59
CE LL-MEDIATED IMMUNE RESPONSE
(CELL-MEDIATED IMMUNITY).......................... 60
CYTOKINES.................................................................. 64
THEORIES OF IMMUNE RESPONSE....................... 71
STUDY QUESTIONS.................................................... 73
SUGGESTED READINGS........................................... 75
Chapter 8 Immunological Tolerance........... 76
CE NTRAL T CELL TOLERANCE TO SELFANTIGENS...............................................................
76
PE RIPHERAL T CELL TOLERANCE TO SELFANTIGENS...............................................................
77
B C ELL TOLERANCE TO SELF-ANTIGENS........... 78
AR TIFICIALLY INDUCED TOLERANCE IN
VIVO......................................................................... 79
STUDY QUESTIONS.................................................... 80
SUGGESTED READINGS........................................... 80
Contents
目 录
XIV 医学免疫学Meeddiiccaall IImmuunnoollooggyy
Chapter 9 Hypersensitivity................................ 81
DEFINITION................................................................. 81
GELL AND COOMBS CLASSIFICATION................ 81
IMMEDIATE TYPE I HYPERSENSITIVITY.............. 81
TY PEⅡ HYPERSENSITIVITY REACTION
(ANTIBODY-DEPENDENT CYTOTOXICITY)........ 89
TY PEⅢ HYPERSENSITIVITY REACTION
(IMMUNE COMPLEX-MEDIATED).................... 93
TY PE Ⅳ CELL-MEDIATED (DELAYED)
HYPERSENSITIVITY.............................................. 96
STUDY QUESTIONS.................................................. 101
SUGGESTED READINGS......................................... 101
Chapter 10 Autoimmunity................................ 102
PR OBABLE MECHANISMS OF
AUTOIMMUNITY................................................ 102
AUTOIMMUNE DISEASES...................................... 107
STUDY QUESTIONS.................................................. 109
Suggested readings......................................... 110
Chapter 11 Immunodeficiency Disorders...... 111
PRIMARY IMMUNoDeFICIENCIES...................... 111
SE CONDARY (ACQUIRED) IMMUNodEFICIENCIES
.................................................................................. 117
STUDY QUESTIONS.................................................. 125
SUGGESTED READINGs......................................... 125
Chapter 12 Tumor Immunology......................... 126
CANCER: ORIGIN..................................................... 126
TUMOR ANTIGENS.................................................. 129
Cancer Immunotherapy................................ 134
STUDY QUESTIONS.................................................. 136
SUGGESTED READINGs......................................... 137
Chapter 13 Transplantation Immunology...... 138
Graft Rejection................................................... 138
FACTORS FAVORINGALLOGRAFT SURVIVAL...... 140
Mechanism Involved in Graft Rejection
................................................................................ 142
Tempo of Rejection............................................ 145
STUDY QUESTIONS.................................................. 147
SUGGESTED READINGS......................................... 147
Chapter 14 Immunological Techniques.......... 149
ST AGES OF ANTIGEN-ANTIBODY
INTERACTIONS.................................................... 149
ME ASUREMENT OF ANTIGEN AND ANTIBODY
................................................................................ 149
PrecipitationReactions................................. 149
Agglutination Reaction............................. 154
MO NOCLONAL ANTIBODIES AND
HYBRIDOMA TECHNIQUE............................. 167
STUDY QUESTIONS.................................................. 170
SUGGESTED READINGs......................................... 171
Chapter 15 Immunoprophylaxis &
Immunotherapy............................... 172
IMMUNOPROPHYLAXIS........................................ 172
IMMUNOTHERAPY.................................................. 179
STUDY QUESTIONS.................................................. 183
SUGGESTED READINGs......................................... 183
Chapter 16 Immunity in Viral, Bacterial,
Fungal, and Parasitic
Infections............................................. 184
IMMU NITY IN VIRALINFECTIONS...................... 184
IMMU NITY IN BACTERIAL INFECTIONS........... 188
IMMU NITY IN FUNGAL INFECTIONS................ 197
IMMU NITY IN PARASITIC INFECTIONS............ 198
STUDY QUESTIONS.................................................. 204
SUGGESTED READINGs......................................... 204
